Is Increased Normal White Matter Glutamate Concentrations a Precursor of Gliosis and Disease Progression in Multiple Sclerosis?

نویسندگان

  • O. D. Leinhard
  • J. Jaworski
  • A. Aalto
  • A. Grönqvist
  • A. Tisell
  • Ö. Smedby
  • A-M. Landtblom
  • P. Lundberg
چکیده

O. D. Leinhard, J. Jaworski, A. Aalto, A. Grönqvist, A. Tisell, Ö. Smedby, A-M. Landtblom, and P. Lundberg Dept of Radiation physics (IMH), Linköping University, Linköping, Sweden, Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, Department of Neurology, Linköping University Hospital, Linköping, Sweden, Dept of Radiology (IMH), Linköping University, Linköping, Sweden, Dept of Radiation Physics (CKOC), Linköping University Hospital, Linköping, Sweden, Division of Clinical Immunology, Unit of Autoimmunity and Immune Regulation (IKE), Linköping University, Linköping, Sweden, Dept of Radiation physics (IMH), Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Brain Metabolite Changes in Patients with Relapsing-Remitting and Secondary Progressive Multiple Sclerosis: A Two-Year Follow-Up Study

Magnetic resonance spectroscopy (MRS) provides the unique ability to monitor several disease-related pathological processes via their characteristic metabolic markers in vivo. In the present study metabolic compositions were assessed every six months over the period of two years in 36 patients with Multiple Sclerosis (MS) including 21 relapsing-remitting (RR), 15 secondary progressive (SP) pati...

متن کامل

Increased Anisotropy in Subcortical Gray Matter Structures: a Neurodegeneration Marker in Multiple Sclerosis

Introduction Multiple Sclerosis (MS) is not only a chronic inflammatory disease characterized by demyelination and gliosis, but the disease also implies neurodegenerative processes. MS exhibits clinically three different forms classified as relapsing-remitting (RR) phases of inflammation followed by a secondary progressive (SP) period, or directly as a primary progressive (PP) evolution which m...

متن کامل

Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T.

Histopathological reports of multiple sclerosis and its animal models have shown evidence of a link between axonal injury in active lesions and impaired glutamate metabolism. Mature oligodendrocytes play a role in glutamate uptake to maintain glutamate homeostasis but in multiple sclerosis white matter the loss of expression of glutamate transporters in the lesion vicinity results in ineffectiv...

متن کامل

ارزش پیش‌گویی‌‌کنندۀ CSF IgG در اسکلروز متعدد: مطالعه در 54 بیمار

Background: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system with multifocal areas of demyelination. Despite an increased understanding of the mechanisms causing MS, immunological factors that indicate disease activity are only starting to be discovered. Chronic brain inflammation is often associated with an increase in production of IgG in the CSF as determined ...

متن کامل

P 16: The Effect of Reducing CCL11 on Multiple Sclerosis Treatment by Using Heterochronic Parabiosis Techniques

Introduction: Multiple sclerosis is a chronic neuroinflammatory disease that leads to distribute neurodegeneration in the grey and white matter of the brain.  In MS, age-related iron accumulation, chronic oxidative injury and activation of microglia are key factors to create neurodegeneration. Also concentration of CCL11 is increased in   multiple sclerosis. CCL11 can amplify glu...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010